Post #6: Clinical Trial NCT00590681 in Chicago
My colleagues at Lilly suggested that I scan the following website to get more information on clinical trials: http://clinicaltrials.gov
And on that website I found the following link:
http://clinicaltrials.gov/ct2/show/NCT00590681
I was intrigued by the science and use of Avastin (Bevacizumab a monoclonal antibody drug made by Genentech) for use in front line therapy in this Phase-2 trial. Avastin has a proven track record for successful secondary treatment of metastatic colorectal cancer. It’s never been used however in brain cancer. The drug works by binding and blocking a protein called vascular endothelial growth factor (VEGF) that blocks the formation of blood vessels that feed new tumor growth and thus the spread and establishment of new tumor growth.
While not as “sexy” as immunotherapy at Duke, the science sounded sound to me and I sent to link to several at Lilly including George Sandusky, Richard Gaynor, and Don Thornton. All agreed that it was a reasonable approach. Geographically, Chicago is a lot closer than Duke to Indianapolis, so that was another plus.
Later that morning (December 9), I “clicked” on the link for the clinical trial NCT00590681 which allowed me to email the lead investigator, Dr. Kelly Nicholas, at the Duchossois Center for Advanced Medicine at the University of Chicago Medical Center on 5758 S. Maryland Ave. Dr. Nicholas emailed me back the next day (December 10) indicated that the trial was still open and then called me in Florida the on December 11 and we had a phone conversation. I filled him in on all the details and told him about my scientific background, he asked me to have my medical records faxed to their facility and Patty also helped me ship the CD versions of my CT & MRI scans from the Florida hospital.
While not yet formally accepted into the clinical trial, Patty & I made the decision to leave Florida and seek treatment in Chicago. It was good for both of us to finally have a plan and begin working on it. It felt like we were moving forward.
With help from our neighbors in Fort Myers (The Hammills and the McManus’s) we prepared our house there for possible rental and boarded a plane on Tuesday, December 16th for Indianapolis. Our good friend, Elaine Sandy picked us up at the Indy airport and our Seidenstein friends dropped off a welcomed dinner for us at our house. Our daughter, Sarah and husband, Thomas joined us for dinner at our house in Indy on this 16-Dec2008. We were at our house less than 24 hours before beginning our drive to downtown Chicago on Wednesday, December 17th.
My colleagues at Lilly suggested that I scan the following website to get more information on clinical trials: http://clinicaltrials.gov
And on that website I found the following link:
http://clinicaltrials.gov/ct2/show/NCT00590681
I was intrigued by the science and use of Avastin (Bevacizumab a monoclonal antibody drug made by Genentech) for use in front line therapy in this Phase-2 trial. Avastin has a proven track record for successful secondary treatment of metastatic colorectal cancer. It’s never been used however in brain cancer. The drug works by binding and blocking a protein called vascular endothelial growth factor (VEGF) that blocks the formation of blood vessels that feed new tumor growth and thus the spread and establishment of new tumor growth.
While not as “sexy” as immunotherapy at Duke, the science sounded sound to me and I sent to link to several at Lilly including George Sandusky, Richard Gaynor, and Don Thornton. All agreed that it was a reasonable approach. Geographically, Chicago is a lot closer than Duke to Indianapolis, so that was another plus.
Later that morning (December 9), I “clicked” on the link for the clinical trial NCT00590681 which allowed me to email the lead investigator, Dr. Kelly Nicholas, at the Duchossois Center for Advanced Medicine at the University of Chicago Medical Center on 5758 S. Maryland Ave. Dr. Nicholas emailed me back the next day (December 10) indicated that the trial was still open and then called me in Florida the on December 11 and we had a phone conversation. I filled him in on all the details and told him about my scientific background, he asked me to have my medical records faxed to their facility and Patty also helped me ship the CD versions of my CT & MRI scans from the Florida hospital.
While not yet formally accepted into the clinical trial, Patty & I made the decision to leave Florida and seek treatment in Chicago. It was good for both of us to finally have a plan and begin working on it. It felt like we were moving forward.
With help from our neighbors in Fort Myers (The Hammills and the McManus’s) we prepared our house there for possible rental and boarded a plane on Tuesday, December 16th for Indianapolis. Our good friend, Elaine Sandy picked us up at the Indy airport and our Seidenstein friends dropped off a welcomed dinner for us at our house. Our daughter, Sarah and husband, Thomas joined us for dinner at our house in Indy on this 16-Dec2008. We were at our house less than 24 hours before beginning our drive to downtown Chicago on Wednesday, December 17th.
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